Strange as it might seem,DeadpoolandSpider-Manhavea “daughter” of sorts in the Marvel Universe– and this character, whose powers are derived from genetic material from both iconic heroes, is poised to make a comeback in the publisher’s mainstream continuity, and fans want to see one version of “Itsy Bitsy” in particular.

2017’sSpider-Man/Deadpool#21 – written by Elliot Kalan, with art by Todd Nauck – featureda variant cover by Ed McGuinness featuring a Venomized version of Itsy Bitsy, and fans have held out hope that this character could make an actual appearance in a story since then. Now, nearly ten years later, the possibility is once more on the table, asItsy Bitsy is rumored to make a return.

Spider-Man/Deadpool #21 cover, featuring a Venomized version of the character “Itsy Bitsy”

As longtimeSpider-Manreaders know, Itsy Bitsy’s unique physiology and ruthless nature set her apart from typical villains, making her a prime candidate for a prominent role in futureSpider-Mancomics.

Underrated Spider-Man Villain “Itsy Bitsy” Is Rumored To Be Making A Comeback, And Fans Want Her Venomized This Time

Deadpool & Spider-Man’s “Daughter,” Explained

Introduced inSpider-Man/Deadpool#8, Itsy Bitsy is a test subject injected with the combined DNA of Spider-Man and Deadpool. This genetic cocktail granted her a range of incredible powers, including spider abilities and a regenerativehealing factor that surpasses even Deadpool’s. Despite her intriguing backstory and potential, Itsy Bitsy has been largely forgotten since her last appearance in 2017. Her return, as teased in upcoming issues ofAmazing Spider-Man, offers Marvel the perfect chance to explore her depth and complexity.

The symbiote’s ability to amplify its host’s traits would likely bring out even more of Itsy Bitsy’s violent tendencies, creating a true wildcard in Spider-Man’s world.

Deadpool and Spider-Man’s daughter, Itsy Bitsy.

A Venomized Itsy Bitsy is the stuff of nightmares; already formidable with her enhanced abilities,adding the symbiote’s power elevates her status among the most dangerous villains in the Spider-Man universe.With her spider-like agility, regenerative abilities, and overwhelming strength, a VenomizedItsy Bitsy would likely push Spider-Man to his limitsin ways few villains ever have. Adding a symbiote to Itsy Bitsy’s already chaotic mix would push her to new extremes. The symbiote’s ability to amplify its host’s traits would likely bring out even more of Itsy Bitsy’s violent tendencies, creating a true wildcard in Spider-Man’s world.

A Venomized Itsy Bitsy Could Be A Major Complicating Factor In Marvel’s Spider-Man Franchise Right Now

Itsy Bitsy’s Return & Her Potential Venomized Form Have Fans Hyped

With her abilities, Itsy Bitsy isan adversary who could force Spider-Man to consider methodshe usually avoids. As a character with a rich backstory Itsy Bitsy deserves a prominent place inSpider-Manlore. If Marvel decides to canonize her Venomized formed, the possibilities for new storylines are extensive;her return, combined with symbiote powers, would undoubtedly add complexity to the Spider-Man mythos, paving the way for thrilling new narratives.With the recent spotlight onMarvel’s symbiotes and their many forms, this seems like an easy way to win over the hearts of longtime fans ofSpider-ManandDeadpool.

Spider-Man/Deadpool#21is available now from Marvel Comics.

Spider-Man

Spider-Man is the name given to several individuals who have employed a spider-moniker throughout Marvel Comics. Typically gaining their powers through a bite from a radioactive spider, the different Spider-Man heroes employ super-strength, agility, and intellect while utilizing webbing to swing and tangle up their foes. The most notable of these Spider-Men is Peter Parker, who remains one of the most popular superheroes throughout the world.

Deadpool

The merc with the mouth first appeared in an issue ofNew Mutantsin 1990, and since then has gone on to get his own series and a massive cult following. With his incredible powers of healing and regeneration, Deadpool was initially depicted as an X-Men villain but went on to become an anti-hero. After getting his own movie series starting in 2016, the third Deadpool movie finally brings the wisecracking, fourth-wall-breaking character into the Marvel Cinematic Universe.

Marvel villain Itsy Bitsy with Spider-Man and Deadpool caught in a web

Spider-Man Swinging in Dodson Comic Art

Deadpool in Comic Cover Art