Warning: Contains SPOILERS for Smile 2!
Drew Barrymore has a small role inSmile 2, with it creating an incredible opportunity for a hilarious payoff 28 years afterScream. Drew Barrymore was famously the opening kill in the originalScream, with her being heavily advertised as part of the film’s marketing campaign only for her to die in the opening minutes. Now that Drew Barrymore has joined anotherfranchise withSmile 2, a sequel can perfectly repeat this career trend.
Drew Barrymore’scameo inSmile 2may be small, but it is one of the film’s most memorable moments. Early inSmile 2,fictional pop singer Skye Riley appears onThe Drew Barrymore Show, with her being a guest on the real-life talk show. Drew Barrymore’sSmile 2appearance helps to flesh out the world of Skye Riley’s stardom, but it also sets up the actress' perfect return inSmile 3.

Drew Barrymore Could Return In Smile 3 As One Of The Curse’s Targets
Paying Off Her Smile 2 Appearance
If Drew Barrymore returns inSmile 3, it would only make sense if she was one of the Smile Curse’s targets. Atthe end ofSmile 2, Skye Riley takes her own life on stage, with the Smile Entity finally killing her during one of her concerts. Due to how the Smile Curse works, this means that the Smile Entity may now possess everyone in attendance at the concert, setting up a terrifying future forSmile 3.
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If thousands of people are possessed with the Smile Curse, that means that it will be spreading around like wildfire. This means that it wouldn’t be a stretch for another celebrity like Drew Barrymore to get possessed, with herSmile 2appearance setting up the possibility of a dark fate for the character inSmile 3.

Smile 3 Could Perfectly Repeat Drew Barrymore’s Scream Role
If She Is Smile 3’s Opening Kill
Having Drew Barrymore return ina potentialSmile 3is an opportunity that shouldn’t be passed up, as it could perfectly repeat the actress' role in the originalScream. Drew Barrymore’s Ghostface death at the beginning of the firstScreamis arguably the actress' most iconic scene, withScreambeing known for killing her off in the opening scene.
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Smile 2 sees the entity messing with Skye in new ways, including through her former best friend, Gemma, and there are clues to this reveal.
IfSmile 3kills Drew Barrymore off in the opening scene, then the film would be the perfect homage to the originalScream. Not only would this be a fantastic gag forScreamfans, but it would also instantly raise the stakes, showing how far the Smile Curse has spread since Skye Riley’s terrifying death at the end ofSmile 2.

Smile 2
Cast
Smile 2 is the sequel to the 2022 psychological horror film by director Parker Finn that centers on a therapist who witnesses a patient’s suicide, leading to a series of terrifying supernatural events. The sequel will see the return of Finn as director, with Paramount continuing distribution.