It takes a certain type of actor to thrive as aScrubsguest star, but there are several figures who would do very well among members of the regular cast in the sitcom’s upcoming revival. Now thatScrubsseason 10 is confirmed, speculation can begin in earnest about what the show’s new era will look like. Although the show’s creator has already revealed he plans to introduce new characters alongside the original cast, that doesn’t mean there won’t be room for visiting stars to make an impact on the story.
Thecharacters who must return forScrubsseason 10 will surely dominate the revival, with their legendary chemistry as an ensemble cast impossible to deny. So, any potential guest stars would also need to boast the same larger-than-life energy demanded by a show likeScrubs. This was proven by the quality of the visiting actors inall nine seasons ofScrubs- althoughthe closestMed Schoolcame to guest stars was established stars like Zach Brafftemporarily returning as Dr. John “JD” Dorian. So, it’s a trend that needs to be quickly reestablished whenScrubsis revived.
10Alan Tudyk
Resident Alien is Tudyk’s subtle Scrubs audition
Tudyk is quietly one of the most in-demand actors of 2025, and there’s a very good reason why he’s so incredibly sought after. In short, he’s versatile. Not only is he willing to step into voice roles that primarily require him to make nonsensical animal noises, like theMoanamovies, but he also lends his voice to massive characters in hugely successful comic book franchises. However,Tudyk has a history with sitcoms, after starring in all three seasons ofSuburgatoryas well as both seasons of the semi-autobiographicalCon Man.
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Although no casting announcements have yet been made, Flynn will presumably return as the Janitor in Scrubs season 10, which will cause an issue.
His most prominent live-action role at the moment is also a great audition for appearing inScrubs. Tudyk has led theResident Aliencastas Harry Vanderspeigle since the show began in 2021. In the adaptation of the comic book series of the same name,Tudyk is required to be incredibly irreverent as well as somehow tug at the viewers' heartstrings- which would allow him to blend in perfectly as a visiting member of theScrubsensemble. His range makes him suitable for a variety of roles, but he’d be great as a particularly quirky patient.
9Leslie David Baker
He wouldn’t need to adjust his famous character from The Office all that much
Most known for playing deadpan paper salesman Stanley Hudson in every season ofThe Office, Baker’s dry sense of humor and straight-as-an-arrow delivery would be great to see in the context of a show likeScrubs.There have been severalScrubscharacters with an ample supply of sass, and Baker would fit in very nicely with that particular brand of cast member. WithScrubsbeginning in 2001 andThe Officemaking its debut four years later, there was a notable period when both shows were airing at the same time.
In terms of who he could play, the passing of Sam Lloyd sadly means Ted the Lawyer won’t be returning for the revival, so the hospital will need a new legal expert.
So, there was a crossover between the respective audiences. Just likeScrubs,The Officeoften championed bizarrely comical momentsbut wasn’t above making things deeply emotional, and Baker’s character had his fair share of being at the heart of these scenes. So, it would just be like slipping into a familiar role. In terms of who he could play, the passing of Sam Lloyd sadly meansTed the Lawyer won’t be returning for the revival, so the hospital will need a new legal expert.
8Zooey Deschanel
Her time on New Girl made sure she was even more ready for a Scrubs role
Deschanel was prioritizing a successful movie career duringScrubs' original run, so it would have been difficult to snag her as a guest star back then. However, she also would have been perfect forScrubsduring that time. Given that she’s roughly the same age as Braff,she would have made a brilliant love interest for JD. WithJD and Elliot finally committing to one another inScrubsseason 8, there’s little chance of a Deschanel guest spot filling that role anymore. Thankfully, there is still room for her in the revival.
As well as her casting in theScrubsrevival being a great idea in its own right, her presence would also bring to mind just how muchScrubsinfluenced future sitcoms.
Modern audiences may be more familiar with Deschanel as the leader of theNew Girlcast, which ran from 2011 to 2018. In many ways, it was a spiritual successor toScrubs, with the close Platonic male relationships between its male cast members being incredibly reflective of Turk (Donald Faison) and JD’s heartwarming dynamic. So, as well as her casting in theScrubsrevival being a great idea in its own right, her presence would also bring to mind just how muchScrubsinfluenced future sitcoms. With Lawrence’s declaration of new characters,Deschanel could easily be a fellow physician.
7Sofía Vergara
Scrubs would benefit from her years on Modern Family
As Gloria Delgado-Pritchett inevery season ofModern Family, Vergara very often stole the show as a key member of the sitcom’s brilliant ensemble cast.She has the perfect level of frantic energy and charisma required to appear inScrubs, and it would certainly be an installment to remember if she were to be cast. Plus, her role in Netflix’sGriseldaproves she’s not just a one-trick pony.
Choosing the bestScrubscasting for an actress like Vergara would be difficult, as she would fit in very well in almost any character archetype. However, there have been examples already inScrubsof glamorous non-medical personnel entering the hospital and causing chaos. For instance, Julianna Margulies’s Neena Broderick inScrubsseason 4, and even Heather Locklear’s Julie Keaton inScrubsseason 2. So, Vergara could play a similar role.
6Tituss Burgess
Scrubs needs another over-the-top figure
Burgess is most known in the sitcom world as part of the tight-knit core cast in all four seasons ofUnbreakable Kimmy Schmidt. As aspiring actor Titus Andromedon, Burgess rarely portrays the character as anything other than self-involved and incredibly over-the-top about pretty much everything. That being said, he does it very, very well. Although he would either dominate theScrubscast or get lost in the wash as a regular star,a guest appearance from Burgess would be thoroughly entertaining.
There is already aScrubscharacter blueprint that would suit Burgess if he were to be cast.
There is already aScrubscharacter blueprint that would suit Burgess if he were to be cast. Although the sitcom’s patients quite often vary on a case-by-case basis, others are far more worried about their health on an almost unreasonable basis. Richard Kind’s returning hypochondriac Harvey Corman is a very good example of one type of patient, and Burgess could take this archetype to a whole new level.He is always dramatic about everything he does inUnbreakable Kimmy Schmidt, so it would work well.
5Katey Sagal
She is the ideal actress to play JD’s mom
Sagal tends to split her time between voice work and live-action roles. At the moment, she is most in the public eye for her return to theFuturamacastas Turanga Leela, as well as starring as Louise inThe Conners. So, she has strong comedic sensibilities, which is essential for a show likeScrubs. Plus, dramatic acting is very much within her skill set, as proven by her work in projects such asSons of Anarchy.
Sagal played the wife of the character of the late John Ritter, and Ritter played JD’s father inScrubsseason 1.
Perhaps the most fittingly meta reason why Sagal would be a greatScrubsguest star relates to her time on8 Simple Rules. On the 2000s sitcom, Sagal played the wife of the character of the late John Ritter, and Ritter played JD’s father inScrubsseason 1. Interestingly,JD’s mother has never appeared onscreen inScrubs, soSagal would be a very clever castingfor the character. Additionally, she’d do a great job.
4Jason Segel
Bill Lawrence’s Shrinking connection makes this far more likely
There was a time when a massive star like Jason Segel would have been beyond the reach of a sitcom likeScrubs. Thankfully, the show’s success set up Bill Lawrence for decades of success. Now,theScrubscreator has curated something of a TV empire, with several active projects on the go at once - primarily with Apple TV+. One of these projects has Segel as one of its main cast members -Shrinking.
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Given how intrinsically tied to the comedy genre Segel has been throughout his career, it’s perhaps surprising that he has done so well as part of theShrinkingcast. The Apple TV+ dramedy allows him to flex acting muscles many viewers didn’t know he had, and with Lawrence’s professional connections to Segel, another partnership seems only fitting. As a nod to his role inShrinking,Segel could once more play a therapist inScrubs. Alternatively, he’d make a great concerned loved one.
3Randall Park
The MCU star would do well in pretty much any Scrubs role
Park may not be the biggest name in the industry, but his comic chops are rivaled by very few. Many may know him as Jimmy Woo in the Marvel Cinematic Universe, but his most-reprised character is actually Louis Huang as part of theFresh off the Boatcast. Over six seasons of the sitcom, Park continued to rattle off brilliant jokes with expert comic timing, andhis overall vibe would nestle in nicely withScrubs'.
He’s part of a rare breed of actors who would succeed in anyScrubsrole given to him.
TheFresh off the Boatstar has a huge level of versatilitywhen it comes to who he could play in theScrubsrevival. Although he would make a great doctor, there’s also a strong argument for him playing an especially awkward patient, or perhaps even a non-medical member of the hospital staff. He’s part of a rare breed of actors who would succeed in anyScrubsrole given to him.
2Aziz Ansari
Ed deserves a revisit so many years after being fired from Sacred Heart
Ansari was briefly a part of theScrubsseason 8 cast as one of the new batch of interns. His character, Ed Dhandapani, was written out of the show shortly after his debut afterAnsari snagged a much bigger role in theParks & Recreationcast. Thankfully, his exit was very well done, asEd was fired by Dr. Cox(John C. McGinley) after several warnings to concentrate on his studies instead of coasting on his natural talent. So, theScrubsrevival could bring him back for a guest appearance.
As Tom Haverford inParks & Rec, Ansari revealed just how great he could have been if he had remained as part of theScrubscast.
As Tom Haverford inParks & Rec, Ansari revealed just how great he could have been if he had remained as part of theScrubscast. Of course, he ultimately made the right decision, asScrubsended after season 9. Regardless,it would be great to see what has become of Ed since his dismissalfrom Sacred Heart. He was clearly a very intelligent character, so it would be interesting to see whether he managed to pull his act together at another hospital or whether he changed careers.
1Andy Samberg
Brooklyn Nine-Nine proved Samberg was born to be in Scrubs
Although most known for his contributions toSNLand his comedy rap bandThe Lonely Island, Samberg very quickly became synonymous with Jake Peralta when he became part of theBrooklyn Nine-Ninecastin 2013. Although his same zany sense of humor remained in place as his detective character, he proved to be a surprisingly capable actor who didn’t shy away from a range of emotional beats. In many ways,Peralta has a lot of parallels with JD, so it’s easy to see them getting along if they were to cross paths inScrubs.
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The Scrubs revival has been confirmed as being a tribute to the past while also looking to the future, but it must make up for one big mistake.
Peralta has struggled to recapture the same level of success sinceBrooklyn Nine-Nineended in 2021, but the projects in which he has appeared continue to prove he would be a great fit forScrubs.There is, of course, the risk of Samberg’s presence stealing the showif he were to make a guest appearance, but the other members of theScrubscast would surely relish the challenge and the privilege of matching Samberg’s unpredictable energy.
Scrubs
Cast
Scrubs is a Sitcom and Medical Comedy/Drama created by Bill Lawrence that follows a group of medical students throughout their daily lives at the Sacred Heart Teaching Hospital. The series stars Zach Braff, Sarah Chalke, and Donald Faison, as they work their way up from Medical Interns while juggling all sorts of hospital shenanigans.
